胡建明导师简介

发布者:yjsbgs发布时间:2018-09-25浏览次数:4282










学位:医学博士

职称:教授/副主任医师

研究领域:病理学-肿瘤免疫,分子病理

邮箱:jianming.120@163.com

办公电话:0993-2850955

通讯地址:yl34511线路中心杏楼办公室112/yl34511线路中心第一附属医院病理科

学术兼职情况:

华中科技大学同济yl34511线路中心兼职教授/博士生导师

兵团医学会病理学分会主任委员

兵团质控中心专家委员会主任委员

中华医学会第十三届病理学分会青年学组委员

中国抗癌协会胃肠间质瘤专业委员会病理协作组委员

中国免疫学新疆肿瘤免疫分会常务理事

新疆第九届病理专业委员青年委员学组副组长

兵团医学会肿瘤学分会常务委员

新疆医学会病理专业委员会病理消化疾病学组成员

兵团医学会肿瘤学分会MDT专业学组成员

兵团英才,yl34511线路中心学科带头人

科研学术工作经历与教育背景:

2006.9-2009.7 石河子大学学院病理学与病理生理学专业,硕士学位

2013.9-2017.7 华中科技大学同济医学院肿瘤专业,博士学位

2005.9-至今 就职于石河子大学学院负责教学、科研工作

科研项目:

1. 主持国家自然科学基金HLA-II类基因调控巨噬细胞在新疆哈族食管鳞癌浸润转移中的作用机制研究No. 81460363(2014-2018)

2. 主持国家自然科学基金肿瘤相关巨噬细胞调控肿瘤干性在哈族食管癌侵袭转移中的作用机制研究No.81760428(2018-2021)

3.主持国家自然科学基金“HIF-1a介导肿瘤相关巨噬细胞促进食管鳞癌浸润转移的作用机制研究”No.81960435(2020-2023)。

4.兵地融合发展“五共同一促进”创建活动专项“智慧模式下全民健康提升项目”子项目负责人,2021.1-2022.12,)

5.主持兵团科技计划“巨噬细胞介导脂代谢促进食管鳞癌化疗抵抗的分子机制研究”,No.2022DZ003,(2022.1-2024.12)。

6.主持yl34511线路中心国际科技合作推进计划项目“靶向纳米TGF-β1siRNA抑制巨噬细胞介导食管鳞癌演进作用机制及治疗策略的研究”No.GJHZ202001

7.主持yl34511线路中心高层次人才科研启动资金“肿瘤相关巨噬细胞介导IL-6/STAT3通路调控食管鳞癌肿瘤细胞干性的作用机制研究”No.RCZK2018C19 (2019.07-2022.07)。

学术论文近五年

1. Yang K, Xie Y, Xue L, Li F, Luo C, Liang W, Zhang H, Li Y, Ren Y, Zhao M, Wang W, Liu J, Shen X, Zhou W, Fei J, Chen W, Gu W, Wang L, Li F, Hu J*. M2 tumor-associated macrophage mediates the maintenance of stemness to promote cisplatin resistance by secreting TGF-β1 in esophageal squamous cell carcinoma. J Transl Med. 2023;21(1):26.(IF=8.440, JCR 1)

2. Zhang AZ, Yuan X, Liang WH, Zhang HJ, Li Y, Xie YF, Li JF, Jiang CH, Li FP, Shen XH, Pang LJ, Zou H, Zhou WH, Li F, Hu JM*. Immune Infiltration in Gastric Cancer Microenvironment and Its Clinical Significance. Front Cell Dev Biol. 2022;9:762029 (IF=6.086, JCR 1).

5. Yuan X, Li Y, Zhang AZ, Jiang CH, Li FP, Xie YF, Li JF, Liang WH, Zhang HJ, Liu CX, Pang LJ, Shen XH, Li F, Hu JM*. Tumor-associated macrophage polarization promotes the progression of esophageal carcinoma. Aging (Albany NY). 2020;13(2):2049-2072(IF=5.955, JCR 1)

3. Jiang CH, Yuan X, Li JF, Xie YF, Zhang AZ, Wang XL, Yang L, Liu CX, Liang WH, Pang LJ, Zou H, Cui XB, Shen XH, Qi Y, Jiang JF, Gu WY, Li F, Hu JM*. Bioinformatics-based screening of key genes for transformation of liver cirrhosis to hepatocellular carcinoma. J Transl Med. 2020;18(1):40.(IF=8.440, JCR 1)

4. Yuan X, Liu K, Li Y, Zhang AZ, Wang XL, Jiang CH, Liang WH, Zhang HJ, Pang LJ, Li M, Yang L, Qi Y, Zheng Q, Li F, Hu JM. HPV16 infection promotes an M2 macrophage phenotype to promote the invasion and metastasis of esophageal squamous cell carcinoma. Clin Transl Oncol. 2021;23(11):2382-2393. (IF=3.340, JCR 2)

5. Qi LW, Jia JH, Jiang CH, Hu JM*. Contributions and Prognostic Values of N6-Methyladenosine RNA Methylation Regulators in Hepatocellular Carcinoma. Front Genet. 2021; 11:1721(IF=4.772, JCR 2)

6. Jiang CH#, Liang WH#, Li FP#, Xie YF, Yuan X, Zhang HJ, Li M, Li JF, Zhang AZ, Yang L, Liu CX, Pang LJ, Li F*, Hu JM*. Distribution and prognostic impact of M1 macrophage on esophageal squamous cell carcinoma. Carcinogenesis. 2021;42(4):537-545(IF=4.741, JCR 1).

7. Yuan X, Zhang AZ, Ren YL, Wang XL, Jiang CH, Yang L, Liu CX, Liang WH, Pang LJ, Gu WY, Li F, Hu JM. Cytokine-induced killer cells/dendritic cells and cytokine-induced killer cells immunotherapy for the treatment of esophageal cancer: A meta-analysis. Medicine (Baltimore). 2021;100(13):e24519.

8. Li J, Xie Y, Wang X, Jiang C, Yuan X, Zhang A, Yang L, Liu C, Zou H, Li F, Hu J*. Identification of hub genes associated with esophageal cancer progression using bioinformatics analysis. Oncol Lett. 2020 Nov;20(5):214. doi: 10.3892/ol.2020.12077SCI 3区).

9. Liu J#, Li C#, Zhang L#, Liu KJiang XWang XYang LLiang WLiu K, Hu J*Li F*. Association of tumour-associated macrophages with cancer cell EMT, invasion, and metastasis of Kazakh oesophageal squamous cell cancer. Diagnostic Pathology. 2019; 14(1):55.SCI 2区).

10. Li JXie YWang XLi FLi SLi MPeng HYang LLiu CPang LZou HZhao JQi YCao YHu J*.Prognostic impact of tumor-associated macrophage infiltration in esophageal cancer: a meta-analysis. Future Oncol. 2019;15(19): 2303-2317. ( SCI 3)

11. Li JXie YWang X, Jiang CH, Yuan Xin, Zhang AZ, Liu CX, Pang LJ, Li F, Hu J* .Overexpression of VEGF-C and MMP-9 predicts poor prognosis in Kazakh patients with esophageal squamous cell carcinoma. PeerJ.2019 Dec 3;7:e8182.SCI 2区)

12. Liu JLiu KJiang XWang XChen YCui XPang LLi SLiu CZou HYang LZhao JQi Y, Hu JM*, Li F* . Clinicopathological significance of Bmi-1 overexpression in esophageal cancer: a meta-analysis. Biomark Med. 2018;12(1):71-81 SCI 3区).

13. Hu JMLiang WHQi CHWang XL , Pan XLQi LWShen XHLi JFXie YFPang LJLiu CXZhang HJTao LLi F. HLA-DQB1*03 and DRB1*07 alleles increase the risk of cervical cancer among Uighur and Han women in Xinjiang, China. Future Oncol. 2018 ;14(20):2005-2011SCI 3区).

14. Hu JM, Liu K, Liu JH, Jiang XL, Wang XL, Chen YZ, Li SG, Zou H, Pang LJ, Liu CX, Cui XB, Yang L, Zhao J, Shen XH, Jiang JF, Liang WH, Yuan XL, Li F. CD163 as a marker of M2 macrophage, contribute to predicte aggressiveness and prognosis of Kazakh esophageal squmous cell carcinoma. Oncotarget. 2017;8(13):21526-21538SCI 1区).

15. Hu JM, Liu K, Liu JH, Jiang XL, Wang XL, Yang L, Chen YZ, Liu CX, Li SG, Cui XB, Zou H, Pang LJ, Zhao J, Qi Y, Liang WH, Yuan XL, Li F. The increased number of tumor-associated macrophage is associated with overexpression of VEGF-C, plays an important role in Kazakh ESCC invasion and metastasis. Exp Mol Pathol. 2017;102(1): 15-21SCI 2区)

16. Wang XL, Liu K, Liu JH, Jiang XL, Qi LW, Xie YF, Li JF, Yang L, Chen YZ, Liu CX, Li SG, Cui XB, Zou H, Pang LJ, Zhao J, Qi Y, Cao YW, Liang WH, Jiang JF, Shen XH, Yuan XL, Hu JM*, Li F*. High infltration of CD68-tumor associated macrophages, predict poor prognosis in Kazakh esophageal cancer patients. Int J Clin Exp Pathol. 2017, 10(10):10282-10292 (SCI 3区)

17.李疆芬,梁伟华,谢玉芳,李锋,李曼,张海俊,沈西华,李丽,庞丽娟,胡建明*。肿瘤干细胞与肿瘤相关巨噬细胞的交互作用。现代免疫学。2020; 40 (4): 325-328

18.谢玉芳,李疆芬,江辰昊,张安志,袁鑫,李范平, 梁伟华,李曼,沈西华, 李丽,崔晓宾,杨兰, 张海俊,庞丽娟,刘春霞,李锋,胡建明*. 基于生物信息学分析的食管癌miRNA-mRNA调控网络的初步构建.农垦医学. 2020; 42(3): 193-199

19.刘凯,刘记红,江现丽,王雪丽,袁野,袁伟媛,王利霞,梁伟华,李锋,胡建明* (通讯作者). 肿瘤相关巨噬细胞与新疆哈萨克族食管鳞癌的相关性分析.西安交通大学学报(医学版). 2018392):256-260.